Stable maintenance of genetic information during meiosis and mitosis is dependent on accurate chromosome transmission. The centromere is a key component of the segregational machinery that couples chromosomes with the spindle apparatus. Most of what is known about the structure and function of the centromeres has been derived from studies on yeast cells. In Saccharomyces cerevisiae, the centromere DNA requirements for mitotic centromere function have been defined and some of the proteins required for an active complex have been identified. Centromere (...) DNA and the centromere proteins form a complex that has been studied extensively at the chromatin level. Finally, recent findings suggest that assembly and activation of the centromere are integrated in tethe cell cycle. (shrink)

The Y chromosomes of most Drosophila species are necessary for male fertility but they are not involved in sex determination. They have many puzzling properties that resemble the effects caused by B chromosomes. Classical genetic and molecular studies reveal substantial affinities between Y and B chromosomes and suggest that the Y chromosomes of Drosophila are not degenerated homologues of the X chromosomes, but rather that their Y chromosomes evolved as specialized supernumeraries similar to classical B chromosomes.

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

En filosofisk hermeneutik -- Hvad værdibegrebet duer til og ikke duer til -- Videnskab og kritik -- Videnskab og ideologi -- Ideologi og sandhed -- Naturdialektik som bidrag til en ædruelig kritik af den instrumentelle fornuft? -- Humanistisk videnskabsteori i en tværfaglig tid -- Hermeneutisk rationalitet -- Habermas versus Krovoza -- Løgstrups sprogfilosofi i dagens kontekst.

During the last decade, Network Science has become one of the most active fields in applied physics and mathematics, since it allows the analysis of a diversity of social, biological and technological systems [24]. From the diversity of applications of Network Science, in this Opinion paper we are concerned about its potential to analyse one of the most extended group sports, Football (soccer in U.S. terminology) [29], since it allows addressing different aspects of the team organization and performance not captured (...) by classical analyses based on the performance of individual players. The reason behind relies on the complex nature of the game, which, paraphrasing the foundational paradigm of complexity sciences “can not be analysed by looking at its components (i.e., players) individually but, on the contrary, considering the system as a whole” or, in the classical words of after-match interviews “it’s not just me, it’s the team”. The recent ability of obtaining datasets of all events occurring during a match, including the position of the players and the interactions between them has opened the door to new kind of studies where it is possible to analyse and quantify the behaviour of a team as a whole, together with the role of a single player [17]. Under this framework, the organization of a team can be considered as the result of the interaction between its players, creating a network based on passes. In this way, we can create passing networks, which are directed (i.e.,... (shrink)

The ground-state dispersion energy of a pair of axially symmetric molecules is calculated, to arbitrary order in the inverse intermolecular separation, on the basis of London's anisotropic oscillator model.

A study is made of the dominant terms of an earlier model-based formula describing the dispersion energy of axially symmetric interacting molecules. The existence of mixed-pole eighth-order terms is noted.

Normativität hat in den Sozialwissenschaften noch immer etwas Anrüchiges, fast Abschreckendes. Es gibt eine lange Traditionslinie in den Sozialwissenschaften, die versucht, ihre Disziplin gegenüber normativen Argumenten „sauber“ zu halten. Das wird in der Regel damit begründet, dass im wissenschaftlichen Erkenntnisprozess Gesinnungsmotive nicht hilfreich sind und im Extremfall Ergebnisse verzerren. Befürworter normativer Sozialwissenschaften halten dagegen, dass die fehlende Thematisierung etwa von sozialen Ungleichheits- und Herrschaftsverhältnissen die Welt, so wie sie gerade ist, einmal mehr bestätigt – und das ist eben auch nicht (...) normfrei und kann es auch nicht sein, weil, so eine zentrale These des vorliegenden Bandes, Theorien notwendig mit normativen Bezügen behaftet sind. Damit ist das Spektrum der Positionen angedeutet, die in diesem Sammelband zu finden sind. Er hat einerseits das Ziel, normative Verwicklungen auch in den sozialwissenschaftlichen Ansätzen aufzuspüren, die stärker auf die Idee einer wertfreien Wissenschaft verpflichtet sind. Andererseits werden Ansätze, die explizit herrschaftskritische Positionen vertreten, auf die Plausibilität ihrer normativen Setzungen hin überprüft. Die normativen Hintergründe sozialwissenschaftlicher Theoriebildung aufzuzeigen und eine Debatte über die normativen Bezüge der Sozialwissenschaften anzuregen ist das Anliegen dieses Bandes. (shrink)

An intercultural framework for servanthood was explored in three Christian community projects. The framework consists of six basic principles, as defined by Duane Elmer, namely openness, acceptance, trust, learning, understanding and serving. This framework is brought into conversation with Miroslav Volf's metaphor of an embrace. In all of this koinonia and diaconia play a pivotal role - especially in the relationship between the two modi. With this hermeneutical framework as point of departure, an empirical study was undertaken to discern the (...) processes and structures within intercultural Christian community projects; and to evaluate the transformation in relationships and the sustainability of the development projects. (shrink)

How does faith-based social involvement within a cultural diverse society express itself? Is the focus pure social outreach, that is, the rendering of services, or should the focus include meaningful interaction between the so called 'outreacher' and those being supported by the outreach? This article looks at the relationship between koinonia and diaconia in the creation of an intercultural space where individuals from different contexts are welcomed and supported in a mutual way. Through an interdisciplinary approach this article reflects on (...) the experience of koinonia and diaconia in the mission of the church by bringing it into an interdisciplinary conversation with Sociology. God's reign become visible if koinonia and diaconia can dance together! (shrink)

After a brief sketch of the state of Buridan studies, this review article examines the recent study, by Benoît Patar, of a commentary on Aristotle’s Physics that is generally attributed to Albert of Saxony, but which Patar believes to have been authored by John Buridan (the text is preserved in the manuscript Bruges, Stadsbibliotheek 477, fols. 60va–163vb, and was edited by Patar himself in 1999). Patar is utterly convinced that the Bruges Quaestiones represent Buridan’s prima lectura, that is, his first (...) course of lectures on the Physics, which preceded the two other redactions that are traditionally attributed to him. However, there is no textual evidence in support of this assumption, but only speculative circumstantial evidence. The article therefore rejects Patar’s thesis as highly problematic. (shrink)